Table 2.
Control | AOE | |
---|---|---|
Cm p/j/a (μF.cm−2) | 0.0184 | 0.0290 |
Cm node (pF) | 0.0327 | 0.247 |
Cm INR (pF) | 0.136 | 0.167 |
gL node (mS.cm−2) | 0.2 | 0.2 |
gL p/j/a (μS.cm−2) | 10.89 | 20.3 |
Passive properties of nodal and INR compartments in control and AOE treated nerves. p/j/a refers to paranodal, juxtaparanodal and axonal regions, all of which express the same values. G refers to conductance and Cm to capacitance. The capacitance and leak current were calculated for each individual INR and node demonstrating that AOE causes an increased INR capacitance due to decreased myelin wraps and increased nodal capacitance and leak current.