Table 1. Population statistics for healthy controls and MCI subjects in the NACC data.
Columns show total subjects, subjects in each genotype, the p-value for the variable being different between ε2/ε3 and ε3 homozygotes, and the p-value for the characteristic being different between ε3 homozygotes and ε3/ε4 heterozygotes. P-values were computed using a logistic regression. Age refers to age at entry into the cohort, number of visits to the number of visits recorded in the database. For continuous values median and interquartile range in brackets are provided, for categorical data, the raw counts as well as percentage are given.
| Total | ε2/ε2 | ε2/ε3 | ε2/ε4 | ε3/ε3 | ε3/ε4 | ε4/ε4 | P-value APOE | P-value sex | ||
|---|---|---|---|---|---|---|---|---|---|---|
| HC | N | 5,496 | 30 | 661 | 139 | 3,210 | 1,320 | 136 | NA | NA |
| Female (%) | 3,652 (66.4) | 19 (63.3) | 456 (69.0) | 96 (69.1) | 2,117 (66.0) | 872 (66.1) | 92 (67.6) | 0.71 | NA | |
| Age | 73.0 [66.6–79.8] | 74.1 [68.1–79.8] | 74.6 [67.1–81.8] | 70.8 [65.3–77.8] | 73.9 [67.4–80.4] | 71.1 [65.5–78.1] | 67.6 [62.1–73.3] | 0.57 | 0.006 | |
| No. of visits | 4 [3–6] | 3.5 [3–4] | 4 [3–6] | 4 [3–5.5] | 4 [3–6] | 4 [3–6] | 4 [2.8–6] | 0.06 | 0.06 | |
| Years of follow-up | 3.9 [2.2–5.5] | 3.6 [2.2–4.3] | 4.0 [2.3–5.7] | 4.0 [2.6–5.2] | 4.0 [2.2–5.5] | 3.9 [2.1–5.4] | 3.3 [2.1–5.3] | 0.27 | 0.40 | |
| Converters (%female) | 964 (60.5) | 2 (0) | 111 (70.3) | 29 (65.5) | 521 (56.6) | 268 (63.1) | 33 (66.7) | 0.08 | 0.000019 | |
| Years of education | 16 [13–18] | 16 [14–18] | 16 [13–18] | 16 [13.5–18] | 16 [14–18] | 16 [14–18] | 16 [14–18] | 0.63 | <2.2e-16 | |
| Non-Hispanic White (%) | 4,458 (81.1) | 20 (66.7) | 524 (79.3) | 101 (72.7) | 2,654 (82.7) | 1,047 (79.3) | 112 (82.4) | 0.06 | 1e-15 | |
| MMSE | 29 [28–30] | 29 [28–30] | 29 [28–30] | 29 [28–30] | 29 [28–30] | 29 [28–30] | 29 [28–30] | 0.68 | 4.4e-11 | |
| MCI | N | 2,588 | 5 | 226 | 70 | 1237 | 858 | 192 | NA | NA |
| Female (%) | 1,275 (49.3) | 3 (60.0) | 117 (51.8) | 35 (50.0) | 602 (48.7) | 425 (49.5) | 93 (48.4) | 0.63 | NA | |
| Age | 74.5 [68.5–80.2] | 82.7 [78.2–84.2] | 76.5 [70.0–83.2] | 74.1 [67.3–82.3] | 75.7 [68.8–81.6] | 73.8 [68.6–79.0] | 70.5 [65.9–74.5] | 0.43 | 1.0 | |
| No. of visits | 4 [2–5] | 3 [2–3] | 3 [3–5] | 3 [2–5] | 4 [3–5] | 3 [2–5] | 4 [3–5] | 0.21 | 0.11 | |
| Years of follow- up | 3.0 [2.0–4.7] | 2.1 [2.1–3.5] | 3.05 [2.03–4.68] | 2.4 [1.6–4.4] | 3.1 [2.0–4.8] | 3.0 [1.8–4.4] | 3.2 [2.1–4.9] | 0.53 | 0.9 | |
| Converters (%female) | 867 (48.8) | 0 (0) | 50 (56.0) | 23 (43.5) | 324 (45.1) | 364 (49.5) | 106 (45.3) | 0.04 | 0.73 | |
| Years of education | 16 [12–18] | 16 [12–16] | 16 [12–18] | 16 [12–18] | 16 [12–18] | 16 [12–18] | 16 [14–18] | 0.84 | <2.2e-16 | |
| Non-Hispanic White (%) | 2,071 (80.0) | 2 (40) | 176 (77.9) | 58 (82.9) | 967 (78.2) | 704 (82.1) | 164 (85.4) | 0.05 | <2.2e-16 | |
| MMSE | 28 [26–29] | 28 [28–29] | 28 [26–29] | 28 [26–29] | 28 [26–29] | 28 [26–29] | 27 [25–29] | 0.31 | 0.19 |