Table 4.
Factors associated with ‘self-determined’ discontinuation of antipsychotic medication during two years of treatment in 380 patients with schizophrenia who received case management and 350 patients who received treatment as usuala
| Odds ratio | 95% Confidence Interval | p | |
|---|---|---|---|
| Received case management | 0.20 | 0.07-0.62 | 0.005 |
| Educational level | |||
| middle school or below | 1.00 | --- | --- |
| high school | 2.04 | 1.27-7.28 | 0.032 |
| college | 2.83 | 0.99-6.21 | 0.052 |
| Medication not supervised by family member | 5.05 | 1.31-12.17 | 0.026 |
| High mean chlorpromazine-equivalent dosage (>400mg/day) | 6.31 | 1.98-21.99 | 0.029 |
| Tolerance of medication | |||
| no discomfort | 1.00 | --- | --- |
| mild discomfort | 1.17 | 0.94-12.60 | 0.053 |
| moderate discomfort | 3.10 | 1.56-16.63 | 0.038 |
| severe discomfort | 7.76 | 2.33-37.23 | 0.010 |
aFactors considered in the backward stepwise regression include group membership, gender, age, education level, duration of illness, type of medication (i.e., typical or new atypical), high (versus low) mean chlorpromazine-equivalent dosage of medication, family member supervision of medication, and medication tolerance (overall mean assessment or the 2-year period by treating clinician).