Table 3.
Interaction between polygenic risk score (PRS) and four childhood trauma domains in predicting all major depressive disorder risk and direct effects of the four childhood trauma domains (n = 1645 cases, n = 340 controls)a
| Emotional neglect (EN) |
Psychological abuse (PsA) |
Physical abuse (PhA) |
Sexual abuse (SA) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EN |
PRS×EN |
PsA |
PRS×PsA |
PhA |
PRS×PhA |
SA |
PRS×SA |
|||||||||
| PRS thresholds | OR | P | OR | P | OR | P | OR | P | OR | P | OR | P | OR | P | OR | P |
|
P<0.001 |
2.57 |
<.001 |
1.10 |
0.307 |
2.40 |
<.001 |
1.03 |
0.809 |
2.90 |
<.001 |
1.24 |
0.297 |
2.19 |
<.001 |
1.12 |
0.503 |
|
P<0.01 |
2.57 |
<.001 |
1.15 |
0.130 |
2.40 |
<.001 |
1.16 |
0.216 |
2.90 |
<.001 |
1.30 |
0.215 |
2.19 |
<.001 |
1.05 |
0.785 |
|
P<0.05 |
2.57 |
<.001 |
1.15 |
0.128 |
2.40 |
<.001 |
1.37 |
0.006 |
2.90 |
<.001 |
1.42 |
0.081 |
2.19 |
<.001 |
1.08 |
0.653 |
|
P<0.1 |
2.57 |
<.001 |
1.18 |
0.069 |
2.40 |
<.001 |
1.36 |
0.007 |
2.90 |
<.001 |
1.36 |
0.137 |
2.19 |
<.001 |
1.11 |
0.508 |
|
P<0.2 |
2.57 |
<.001 |
1.21 |
0.032 |
2.40 |
<.001 |
1.29 |
0.025 |
2.90 |
<.001 |
1.23 |
0.288 |
2.19 |
<.001 |
1.10 |
0.561 |
|
P<0.3 |
2.57 |
<.001 |
1.22 |
0.027 |
2.40 |
<.001 |
1.36 |
0.007 |
2.90 |
<.001 |
1.18 |
0.381 |
2.19 |
<.001 |
1.12 |
0.460 |
|
P<0.4 |
2.57 |
<.001 |
1.21 |
0.035 |
2.40 |
<.001 |
1.32 |
0.016 |
2.90 |
<.001 |
1.11 |
0.577 |
2.19 |
<.001 |
1.14 |
0.393 |
| P<0.5 | 2.57 | <.001 | 1.19 | 0.056 | 2.40 | <.001 | 1.31 | 0.018 | 2.90 | <.001 | 1.10 | 0.609 | 2.19 | <.001 | 1.16 | 0.356 |
OR, odds ratio.
a.
Four childhood trauma domains (ranging from 0 to 2) were tested for their direct effects and interaction effects with polygenic risk scores on all major depressive disorder risk, using logistic regression analyses adjusted for age, gender and three principal components. The main effects of the PRSs are displayed in Table 2 (model 1).