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Model of PKA-dependent phosphorylated regulation of HDAC4. PKA phosphorylates HDAC4 in the nucleus, especially inducing phosphorylation of HDAC4 at serine 740, which results in HDAC4 being released from Runx2 bound to the Runt domain site of the MMP-13 promoter. PKA phosphorylation also induces dephosphorylation of HDAC4 at serine 355 in the nucleus. After transport of HDAC4 into the cytoplasm, HDAC4 is partially degraded through the lysosomal pathway.
