Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jun 14;289(31):21473–21489. doi: 10.1074/jbc.M114.581702

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 10. — Reversal of collateral sensitivity of KB-V1 cells to tiopronin by ROS scavengers, assessed by cytotoxicity assay. A, dose-response curves of the P-gp-expressing subline KB-V1 and the parental KB-3-1 human adenocarcinoma cell line treated with tiopronin for 72 h, showing the effect of increasing (nontoxic) concentrations of N-acetylcysteine (1, 2, and 5 mm) on the cytotoxicity of tiopronin toward KB-V1 and KB-3-1 cells. B, effect of anoxic conditions on the cytotoxicity of tiopronin toward KB-V1 and KB-3-1 cells. C, effect of catalase and inactivated catalase (generated by heating lysate at 65 °C for 4 h) added to growth media on the cytotoxicity of tiopronin toward KB-V1 and KB-3-1 cells. D, effect of erythrocyte (RBC) lysate and inactivated RBC lysate (generated by heating lysate at 65 °C for 4 h), added to growth media on the cytotoxicity of tiopronin toward KB-V1 and KB-3-1 cells.