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. 2014 Jun 14;289(31):21473–21489. doi: 10.1074/jbc.M114.581702

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 11. — Collateral sensitivity of KB-V1 cells to NSC73306, assessed by cytotoxicity assays. A, dose-response curves of NSC73306 against the P-gp-expressing sublines KB-V1 and the parental KB-3-1 human adenocarcinoma cell line treated with NSC73306 for 72 h. B, effect of increasing (nontoxic) concentrations of N-acetylcysteine on the cytotoxicity of NSC73306 toward KB-V1 and KB-3-1 cells. C, effect of anoxic conditions on the cytotoxicity of NSC73306 toward KB-V1 and KB-3-1 cells. D, false-positive effect of inactivated catalase (generated by freeze-thaw cycles) on the cytotoxicity of NSC73306 toward both KB-V1 and KB-3-1 cells.