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Knockdown of GPx1 and/or GPx4 reverses selective killing by tiopronin. A, Western blot of GPx1 and GPx4 in KB-3-1 and KB-V1 cells transfected with shRNA that is NT or targeted against GPx1, GPx4, or GPx1 and GPx4 (GPx1 + 4). B and C, dose-response curves of KB-V1 and KB-3-1 GPx1 + 4 and NT cells treated with luperox (B) or tiopronin (C) for 72 h.
