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Inhibition of autoactivation by cathepsin K specific inhibitors. Inhibition of processing of pro-hrCatK (4 μm) was demonstrated by varied concentrations of the reversible CatK specific inhibitor L-235 (A) and covalent cathepsin inhibitor E-64 (B). Reaction mixture containing 18 μm C4-S was incubated at 37 °C for 6 h. Lane 0, pro-hrCatK without L-235 after incubation at 37 °C; lane 00, pro-hrCatK without L-235, stored at 0 °C prior processed for Western blot.
