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. 2014 Jun 19;289(31):21640–21650. doi: 10.1074/jbc.M114.578765

FIGURE 4.

FIGURE 4.

Alignment of human porin, human Tom40, and NcTom40 with SCAM results. The amino acid sequence of porin from Homo sapiens (Hs) is shown in the top two sequences. In the first (Hs p_BIO) the position of the 13 β-strands predicted by the BIO model (36) are shown (highlighted and numbered in red). An asterisk (*) represents a sharp (zero residue) hairpin loop between β-strands 7 and 8 in the BIO model. The second sequence (Hs p_3D) shows the position (green) of the 19 β-strands from the three-dimensional structures of porin. The third sequence (Hs Tom40) shows the position (yellow) of the 19 β-stands predicted to exist in human Tom40 (11–13). The bottom sequence (Nc Tom40) represents the NcTom40 showing the predicted 19 β-strands (highlighted and numbered in teal). The position and alignment of strands in the last three sequences are as previously described (12). The SCAM results from this study are displayed below the NcTom40 sequence. Positive (+) and negative (−) labeling signals are indicated. SCAM results that suggest the position of a β-strand are shown as highlighted black bars below the sequence.