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Working model. The TORC2-Gad8 pathway is positively regulated by cAMP/PKA1 and negatively regulated by the PmK1-MAPK pathway. In the presence of glucose, the PKA pathway is activated in a cAMP-dependent manner, leading to the activation of TORC2-Gad8. The Pmk1-MAPK pathway is activated under glucose starvation conditions, leading to inhibition of TORC2-Gad8, via inhibition of the Pka1 pathway or via an independent mechanism.
