Figure 2.

Superposition of representative NCS protein structures in the Ca²⁺-bound form. Front (a) and back (b) cartoon representations of myrGCAP1 superimposed onto the NCS family members myr-recoverin, neurocalcin, NCS-1 and KChIP1. The coloring of myrGCAP1 is as in Fig. 1 with the N- and C-terminal helices in bright red and green, respectively. The other NCS proteins are colored light yellow for EF-hands 1 and 2 and light orange for EF-hands 3 and 4, dark red for the N-terminal helix and dark green for the C-terminal segment. The recoverin myristoyl group is shown as a space-filling model in light blue. Ca²⁺ ions bound to GCAP1 are shown in dark green for reference but are omitted for the other NCS proteins for clarity.