Table 1. Mutations (including Missense point mutations/deletion/insertion) frequencies in 45 genes (737 loci) in female and male GISTs. The p-value of Fisher exact test result of KIT mutations in female and male is 0.429.
Genes | Number of samples with mutations (Mutation frequency in 121 samples) | Number of female samples with mutations (Mutation frequency in 59 female samples) | Number of male samples with mutations (Mutation frequency in 62 male samples) |
---|---|---|---|
ABL1 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
AKT1 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
ALK | 0(0.0%) | 0(0.0%) | 0(0.0%) |
APC | 0(0.0%) | 0(0.0%) | 0(0.0%) |
ATM | 0(0.0%) | 0(0.0%) | 0(0.0%) |
BRAF | 1(0.8%) | 0(0.0%) | 1(1.6%) |
CDH1 | 1(0.8%) | 0(0.0%) | 1(1.6%) |
CDKN2A | 0(0.0%) | 0(0.0%) | 0(0.0%) |
CSF1R | 0(0.0%) | 0(0.0%) | 0(0.0%) |
CTNNB1 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
EGFR | 1(0.8%) | 1(1.7%) | 0(0.0%) |
ERBB2 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
ERBB4 | 1(0.8%) | 1(1.7%) | 0(0.0%) |
FBXW7 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
FGFR1 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
FGFR2 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
FGFR3 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
FLT3 | 3(2.5%) | 2(3.4%) | 1(1.6%) |
GNAS | 0(0.0%) | 0(0.0%) | 0(0.0%) |
HNF1A | 0(0.0%) | 0(0.0%) | 0(0.0%) |
HRAS | 0(0.0%) | 0(0.0%) | 0(0.0%) |
IDH1 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
JAK3 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
KDR | 0(0.0%) | 0(0.0%) | 0(0.0%) |
KIT | 60(49.6%) | 25(42.4%) | 35(56.5%) |
KRAS | 1(0.8%) | 1(1.7%) | 0(0.0%) |
MET | 0(0.0%) | 0(0.0%) | 0(0.0%) |
MLH1 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
MPL | 0(0.0%) | 0(0.0%) | 0(0.0%) |
NOTCH1 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
NPM1 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
NRAS | 0(0.0%) | 0(0.0%) | 0(0.0%) |
PDGFRA | 1(0.8%) | 1(1.7%) | 0(0.0%) |
PIK3CA | 0(0.0%) | 0(0.0%) | 0(0.0%) |
PTEN | 1(0.8%) | 1(1.7%) | 0(0.0%) |
PTPN11 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
RB1 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
RET | 0(0.0%) | 0(0.0%) | 0(0.0%) |
SMAD4 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
SMARCB1 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
SMO | 0(0.0%) | 0(0.0%) | 0(0.0%) |
SRC | 0(0.0%) | 0(0.0%) | 0(0.0%) |
STK11 | 0(0.0%) | 0(0.0%) | 0(0.0%) |
TP53 | 1(0.8%) | 0(0.0%) | 1(1.6%) |
VHL | 1(0.8%) | 0(0.0%) | 1(1.6%) |