Table 6. Mutations (including Missense point mutations/deletion/insertion) frequencies in 45 genes (737 loci) in CD34+ and CD34− GISTs.
| Genes | Number of samples with mutations in 121 samples (Mutation frequency) | Number of unknown samples with mutations (Mutation frequency in 56 unknown samples) | Number of CD34(+) samples with mutations (Mutation frequency in 20 CD34(+) samples) | Number of CD34(++) samples with mutations (Mutation frequency in 16 CD34(++) samples) | Number of CD34(+++) samples with mutations (Mutation frequency in 17 CD34(+++) samples) | Number of CD34(−) samples with mutations (Mutation frequency in 12 CD34(−) samples) |
|---|---|---|---|---|---|---|
| ABL1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| AKT1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| ALK | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| APC | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| ATM | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| BRAF | 1(0.8%) | 0(0.0%) | 0(0.0%) | 1(6.2%) | 0(0.0%) | 0(0.0%) |
| CDH1 | 1(0.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 1(10.0%) |
| CDKN2A | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| CSF1R | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| CTNNB1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| EGFR | 1(0.8%) | 0(0.0%) | 1(5.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| ERBB2 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| ERBB4 | 1(0.8%) | 1(1.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| FBXW7 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| FGFR1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| FGFR2 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| FGFR3 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| FLT3 | 3(2.5%) | 0(0.0%) | 1(5.0%) | 1(6.2%) | 1(5.9%) | 0(0.0%) |
| GNAS | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| HNF1A | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| HRAS | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| IDH1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| JAK3 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| KDR | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| KIT | 60(49.6%) | 26(46.4%) | 11(55.0%) | 9(56.2%) | 9(52.9%) | 5(41.7%) |
| KRAS | 1(0.8%) | 1(1.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| MET | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| MLH1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| MPL | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| NOTCH1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| NPM1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| NRAS | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| PDGFRA | 1(0.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 1(5.9%) | 0(0.0%) |
| PIK3CA | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| PTEN | 1(0.8%) | 0(0.0%) | 1(5.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| PTPN11 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| RB1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| RET | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| SMAD4 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| SMARCB1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| SMO | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| SRC | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| STK11 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| TP53 | 1(0.8%) | 1(1.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
| VHL | 1(0.8%) | 1(1.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |