Table 6. Mutations (including Missense point mutations/deletion/insertion) frequencies in 45 genes (737 loci) in CD34+ and CD34− GISTs.
Genes | Number of samples with mutations in 121 samples (Mutation frequency) | Number of unknown samples with mutations (Mutation frequency in 56 unknown samples) | Number of CD34(+) samples with mutations (Mutation frequency in 20 CD34(+) samples) | Number of CD34(++) samples with mutations (Mutation frequency in 16 CD34(++) samples) | Number of CD34(+++) samples with mutations (Mutation frequency in 17 CD34(+++) samples) | Number of CD34(−) samples with mutations (Mutation frequency in 12 CD34(−) samples) |
---|---|---|---|---|---|---|
ABL1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
AKT1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
ALK | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
APC | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
ATM | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
BRAF | 1(0.8%) | 0(0.0%) | 0(0.0%) | 1(6.2%) | 0(0.0%) | 0(0.0%) |
CDH1 | 1(0.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 1(10.0%) |
CDKN2A | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
CSF1R | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
CTNNB1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
EGFR | 1(0.8%) | 0(0.0%) | 1(5.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
ERBB2 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
ERBB4 | 1(0.8%) | 1(1.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
FBXW7 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
FGFR1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
FGFR2 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
FGFR3 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
FLT3 | 3(2.5%) | 0(0.0%) | 1(5.0%) | 1(6.2%) | 1(5.9%) | 0(0.0%) |
GNAS | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
HNF1A | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
HRAS | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
IDH1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
JAK3 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
KDR | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
KIT | 60(49.6%) | 26(46.4%) | 11(55.0%) | 9(56.2%) | 9(52.9%) | 5(41.7%) |
KRAS | 1(0.8%) | 1(1.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
MET | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
MLH1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
MPL | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
NOTCH1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
NPM1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
NRAS | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
PDGFRA | 1(0.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 1(5.9%) | 0(0.0%) |
PIK3CA | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
PTEN | 1(0.8%) | 0(0.0%) | 1(5.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
PTPN11 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
RB1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
RET | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
SMAD4 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
SMARCB1 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
SMO | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
SRC | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
STK11 | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
TP53 | 1(0.8%) | 1(1.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |
VHL | 1(0.8%) | 1(1.8%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) |