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. 2014 Jul 22;11:33. doi: 10.1186/1742-4682-11-33

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Copyright © 2014 Polidori and Rowley; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Errors in estimating plasma volume by back-extrapolation for different clearance rates and different back-extrapolation times. In panel A, the ratio of the estimated PV to the true PV is shown for a range of ICG clearance in the simulations for two different back-extrapolation times (t = 0 and t = 1.08 min). Note that low values of α correspond to low clearance rates and, for values of α >100, there is nearly complete extraction of ICG by the liver. In panel B, the percentage error is the estimated PV is shown as a function of the back-extrapolation time used for simulations performed with clearance parameter α = 29 (for this value of α, the simulated plasma ICG profile is similar to the mean plasma ICG profile observed in the clinical study [12]). PV, plasma volume; ICG, indocyanine green.