Fig. 1.

Compartmentalization of antigen presenting cells (APC) within splenic red and white pulp regions. Both CD8⁺cDC and white pulp macrophages (WPM) lie in the T cell zone, whereas marginal-zone metallophilic macrophages (MMM), marginal-zone macrophages (MZM) and CD8⁻ cDC lie within the marginal zone. Red pulp macrophages (RMP) are localized in the red pulp. The tentative location of L-DC within the red pulp region is based on experimental verification of high accessibility for blood-borne antigen compared with other DC subsets.