Table 3.
Summarized results of in vitro analyses (observed effects of particular pre- and anti-miR oligonucleotides)
| pre-miR-378 | pre-miR-422a | pre-miR-375 | pre-miR-215 | anti-miR-135b | ||
|---|---|---|---|---|---|---|
| HCT-116 cells | ||||||
| Apoptosis | – | – | – | Increased apoptosis P = 0.005 | – | |
| Cell cycle | G1/S increased P = 0.005 | G1/S increased P = 0.01 | G1/S increased P = 0.01 | G1/S increased P = 0.01 | – | |
| MTT | Trend (P > 0.05) | – | Decreased viability P = 0.005 | Decreased viability P = 0.05 | Decreased viability P = 0.05 | |
| SWA* | – | Trend (P > 0.05) | – | Trend (P > 0.05) | – | |
| DLD-1 cells | ||||||
| Apoptosis | – | – | – | – | – | |
| Cell cycle | – | – | – | – | – | |
| MTT | Trend (P > 0.05) | – | Trend (P > 0.05) | Decreased viability P = 0.05 | Decreased viability P = 0.005 | |
| SWA | – | Trend (P > 0.05) | – | Decreased viability P = 0.05 | – | |
SWA, scratch wound assay.