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. Author manuscript; available in PMC: 2015 Jan 3.
Published in final edited form as: Semin Reprod Med. 2014 Jan 3;32(1):56–67. doi: 10.1055/s-0033-1361823

Figure 2. Repeated exposure to IA LPS or a chronic exposure to IA U. parvum induces endotoxin tolerance in preterm lambs.

Figure 2

IL-1ß mRNA expression was measured in the lung obtained at autopsy from sheep delivered at 125d gestational age (80% gestation). (A) Compared to a single exposure to IA LPS (E. coli lipopolysaccharide) 2d before delivery, a second exposure to IA LPS 7d before delivery decreased IL-1ß mRNA expression induced by IA LPS 2d prior to delivery B) A chronic exposure to live UP (U. parvum) given 70d before delivery decreased lung IL-1ß mRNA induced by IA LPS 2d prior to delivery. In frame A IL-1ß expression was measured by a RNAse protection assay while frame B used quantitative rt-PCR using Taqman probes accounting for the different values (*p<0.05 vs. IA LPS 2d, Data from [60] and [65]).