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. Author manuscript; available in PMC: 2015 Jan 3.
Published in final edited form as: Semin Reprod Med. 2014 Jan 3;32(1):56–67. doi: 10.1055/s-0033-1361823

Figure 3. IA IL-1ß induces changes in the Tregs and IL-17 producing cells in the mesenteric lymph node but not the blood in preterm rhesus macaques.

Figure 3

Changes in the frequency of Tregs (CD4+, FOXP3+) and IL-17 producing CD3+ CD4+ cells were measured by flow cytometry 1d or 3d after IA IL-1ß in rhesus macaques delivered at 80% gestation. Note the large dynamic changes with an initial reduction and a subsequent rebound in Tregs in the mesenteric LN (lymph node). The changes in IL-17 producing cells were reciprocal to the Treg frequency in the mesenteric LN. In contrast no changes in either Tregs or IL-17+ cells were detected in the blood mononuclear cells. (*p<0.05 vs. control, #p<0.05 vs. IA IL-1ß (1d), Data from [20]).