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. 2014 Jul 9;15:81. doi: 10.1186/1471-2156-15-81

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Copyright © 2014 Scharpf et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The relationship between integer copy number (x-axis) and average log uric acid concentrations is approximately linear. Slopes for the copy number coefficients at the chromosome 4 CNP-9 Mb (top) and CNP-10 Mb (bottom) loci overlay the empirical average log uric acid concentration with error bars drown to ± two standard errors of the mean. The opposite signs of the regression slopes at CNP-9Mb and CNP-10Mb is a reflection of linkage disequilibrium – the copy number estimates have a strong, negative correlation (Spearman correlation = -0.82).