Table 2.

Single-marker and meta-analysis results for the most significant SNPs within AβPP, PSEN1, PSEN2, and MAPT, plus the H1 haplotype tag SNP rs9468, within three independent LOAD GWAS samples (GERAD1, TGEN, and ADNI)

Gene	SNP ID	GERAD1			TGEN			ADNI			Meta-analysis
		Info	OR	p value	RSQR	OR	p value	Info	OR	p value	OR	p value	Q-statistic	I2
AβPP	rs381743	0.87	0.91	0.002	0.96	0.97	0.789	N/A	N/A	N/A	0.92	0.003	0.586	0
PSEN1	chr14-72745579	0.80	1.36	1.9 × 10−4	0.71	0.75	0.378	N/A	N/A	N/A	1.10	0.743	0.071	69
PSEN2	rs12405469	0.81	0.94	0.041	0.99	1.06	0.573	N/A	N/A	N/A	0.95	0.072	0.264	20
MAPT	rs11656151	0.84	1.13	8.8 × 10−5	0.89	1.08	0.538	0.95	1.21	0.283	1.13	4.7 × 10−5	0.855	0
MAPT	rs9468	0.87	0.89	7.8 × 10−4	0.95	0.96	0.725	0.98	0.83	0.289	0.89	5.2 × 10−4	0.786	0

Inverse variance weights (IVW) meta p-values were calculated from summary statistics. Odds ratios (OR) refer to the minor allele. Meta p-values given are based on a fixed effect model unless Q statistic p < 0.1 or I² > 50. In these instances a random effects model was used.

N/A = Not available.