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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Stem Cell Res. 2014 Apr 22;13(1):154–163. doi: 10.1016/j.scr.2014.04.005

Figure 6. Castration induces selective proliferation of 4-markers progenitor cells.

Figure 6

Eight week old mice were sham operated or castrated. BrdU was injected daily after surgery to label the proliferating cells, and mice were sacrificed 2 weeks after castration. (A) FACS analysis showed significantly higher labeling of 4-marker cells in the castrated versus sham operated mice (16% versus 3.7%; 3 independent experiments; Figure 6A). These data signify increased proliferation of 4-marker cells in the castrated mouse prostate. (B) Proliferation was greater in 4-marker progenitor cells than that in non- 4-marker positive cells in the castrated prostate group (n=3). Taken together, these data indicate that castration induces preferential proliferation of 4-marker cells.