Table 1.
Volunteer demographics.
| N (Patients) |
Age (yrs) | Sex (M/F) |
Anti- platelet (Fraction) |
Anti- coagulant (Fraction) |
Cardiovascular Risk Factors (Fraction) |
Diabetes (Fraction) |
Smoking (Fraction) |
Presence of Infarct (Fraction) |
|
|---|---|---|---|---|---|---|---|---|---|
| Healthy Control | 10 | 33.1±8.5 | 5/5 | 0.00 | 0.00 | 0.00 | 0.10 | 0.10 | 0.00 |
| BOLD vs. CBF Reactivity | 57 | 51.2±16.5 | 22/35 | 0.88 | 0.09 | 0.84 | 0.35 | 0.42 | 0.93 |
| Lateralizing CVR | |||||||||
| Total | 60 | 51.7±15.7 | 22/38 | 0.81 | 0.06 | 0.79 | 0.29 | 0.29 | 0.79 |
| Atherosclerotic* | 31 | 59.8±13.2 | 15/16 | 0.73 | 0.12 | 0.91 | 0.36 | 0.48 | 0.85 |
| Moyamoya** | 29 | 41.8±12.7 | 7/22 | 0.90 | 0.00 | 0.66 | 0.21 | 0.21 | 0.72 |
| Safety | N (Patient Scans) |
Age (yrs) | Sex (M/F) |
Athero- sclerotic (Fraction) |
Moyamoya (Fraction) |
Other (Fraction) |
Stroke- related symptoms (Fraction) |
Other symptoms (Fraction) |
Follow-up duration (median;days) |
|---|---|---|---|---|---|---|---|---|---|
| Immediate follow-up | 125 | 50.6±16.0 | 53/72 | 0.35 | 0.52 | 0.13 | 0.00 | 0.02 | 0.00 |
| Longer-term Follow-up | 125 | 50.6±15.6 | 53/72 | 0.35 | 0.52 | 0.13 | 0.05 | 0.27 | 372 |
*
For multivariate analysis, asymmetry between affected and contralateral CVR (t-statistic) was used (i.e., n=31 measurements).
**
For multivariate analysis, to minimize over-fitting concerns, each hemisphere was considered separately (n=58) and hemisphere modified Suzuki Score added as a predictor. See Supplementary Material for details.