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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Adv Immunol. 2013;118:37–128. doi: 10.1016/B978-0-12-407708-9.00002-9

Figure 2.6.

Figure 2.6

The IL17A/IL17F locus. Comparative histone posttranslational modifications, DNA methylation status, and intrachromosomal interactions are shown for the murine Il17a/Il17f locus in naïve CD4+ T, Th1, Th2, and Th17 cells. Position and transcriptional orientation of the Il17a, IL17f, Mcm3, and Phkd1 genes (gray boxes, arrows) and regulatory elements (black boxes) are shown, with sequence names indicated at the bottom. Red bars indicate the position of permissive histone modifications: H3 and H4 histone acetylation and trimethylation (3) at H3K4. Green bars indicate regions associated with the repressive histone mark H3K27me3. Regions of CpG hypomethylation and methylation are indicated by open and filled blue boxes, respectively. Intrachromosomal interactions that form in a Th17-specific fashion are shown by arrows at the bottom. ND, not determined in a given cell type.