Table 1.
Personal and household associations of childhood atopic dermatitis severity (n=79,667).
| Variable | Subgroup | Atopic dermatitis severity | ||||||
|---|---|---|---|---|---|---|---|---|
| Mild (n = 7198) | Moderate (n = 2612) | Severe (n = 576) | ||||||
| Freq | Percent (95% CI) | Freq | Percent (95% CI) | Freq | Percent (95% CI) | P-value* | ||
| Age (yr) | <1 | 392 | 76.9 (69.9 – 84.0) | 93 | 17.7 (11.2 – 24.2) | 25 | 5.4 (2.0 – 8.7) | 0.0003 |
| 1-3 | 1182 | 76.2 (72.2 – 80.2) | 352 | 18.6 (15.2 – 22.0) | 61 | 5.2 (2.8 – 7.6) | ||
| 3-7 | 1890 | 67.7 (63.3 – 72.2) | 648 | 27.1 (22.9 – 31.3) | 123 | 5.2 (2.9 – 7.4) | ||
| 7-13 | 2003 | 63.1 (59.0 – 67.3) | 784 | 27.8 (24.0 – 31.5) | 196 | 9.1 (6.4 – 11.9) | ||
| 13-17 | 1731 | 62.6 (57.4 – 67.7) | 735 | 29.5 (24.3 – 34.6) | 171 | 8.0 (5.7 – 10.3) | ||
| Sex | Male | 3725 | 65.0 (61.9 – 68.1) | 1354 | 26.9 (24.1 – 29.8) | 295 | 8.1 (6.0 – 10.1) | 0.12 |
| Female | 3466 | 68.9 (65.8 – 72.1) | 1258 | 25.1 (22.0 – 28.2) | 281 | 6.0 (4.7 – 7.3) | ||
| Race/ethnicity | Hispanic | 801 | 61.8 (54.2 – 69.4) | 324 | 30.2 (22.7 – 37.7) | 85 | 8.0 (3.9 – 12.2) | <0.00001 |
| White, non-Hispanic | 4500 | 71.8 (69.2 – 74.3) | 1530 | 23.1 (20.8 – 25.4) | 285 | 5.1 (3.8 – 6.5) | ||
| African American, non-Hispanic | 1045 | 60.5 (55.5 – 65.4) | 435 | 28.4 (23.6 – 33.2) | 135 | 11.2 (8.1 – 14.3) | ||
| Multi/Other, non-Hispanic | 741 | 66.5 (60.3 – 72.8) | 282 | 29.8 (23.6 – 36.0) | 54 | 3.6 (2.0 – 5.3) | ||
| Child's birthplace in the US | No | 123 | 78.4 (68.6 – 88.3) | 40 | 13.4 (6.5 – 20.2) | 11 | 8.2 (1.6 – 14.9) | 0.04 |
| Yes | 7004 | 66.7 (64.5 – 69.0) | 2548 | 26.3 (24.2 – 28.4) | 570 | 7.0 (5.7 – 8.2) | ||
| Household income | 0-99% FPL | 779 | 58.3 (52.8 – 63.8) | 339 | 27.5 (22.7 – 32.3) | 128 | 14.2 (10.1 – 18.3) | <0.0001 |
| 100-199% FPL | 1137 | 64.2 (59.2 – 69.1) | 470 | 27.4 (22.6 – 32.2) | 146 | 8.4 (6.0 – 10.9) | ||
| 200-399% FPL | 2395 | 66.9 (62.8 – 71.0) | 897 | 27.8 (24.0 – 31.7) | 131 | 5.3 (3.0 – 7.5) | ||
| ≥400% FPL | 7198 | 74.0 (70.3 – 77.8) | 2612 | 22.2 (18.6 – 25.8) | 576 | 3.7 (2.2 – 5.3) | ||
| Primary language spoken in home | English | 6843 | 66.7 (64.4 – 69.0) | 2478 | 26.1 (24.0 – 28.3) | 550 | 7.2 (5.9 – 8.5) | 0.27 |
| Not English | 352 | 71.3 (63.4 – 79.2) | 133 | 24.4 (16.9 – 31.9) | 25 | 4.3 (2.1 – 6.6) | ||
| Number of children in household | 1 | 2950 | 67.5 (64.1 – 70.8) | 1041 | 24.8 (22.0 – 27.6) | 229 | 7.8 (5.2 – 10.3) | 0.03 |
| 2 | 2783 | 67.4 (63.9 – 80.8) | 1008 | 26.7 (23.4 – 30.0) | 206 | 5.9 (4.2 – 7.7) | ||
| 3 | 1027 | 64.2 (59.0 – 69.4) | 415 | 29.4 (24.2 – 34.6) | 95 | 6.4 (4.2 – 8.6) | ||
| ≥4 | 438 | 71.2 (64.4 – 78.0) | 148 | 17.7 (12.9 – 22.4) | 46 | 11.1 (5.8 – 16.4) | ||
| Birth order in families with 2 or more children | Oldest child | 2950 | 67.5 (64.1 – 70.8) | 1041 | 24.8 (22.0 – 27.6) | 229 | 7.8 (5.2 – 10.3) | 0.02 |
| 2nd oldest child | 1644 | 63.5 (58.6 – 68.4) | 606 | 29.8 (25.0 – 34.6) | 134 | 6.7 (4.1 – 9.3) | ||
| 3rd oldest child | 1935 | 65.2 (61.3 – 69.2) | 730 | 27.8 (24.0 – 31.7) | 157 | 6.9 (4.9 – 9.0) | ||
| ≥4th oldest child | 502 | 75.8 (70.2 – 81.5) | 185 | 17.5 (12.7 – 22.3) | 41 | 6.6 (3.4 – 9.8) | ||
| Family structure | Two parent biological/adopted | 5084 | 70.5 (67.8 – 73.1) | 1724 | 25.3 (22.8 – 27.8) | 287 | 4.2 (3.0 – 5.5) | <0.0001 |
| Two parent stepfamily | 415 | 64.7 (56.0 – 73.4) | 194 | 26.4 (17.9 – 34.9) | 58 | 8.9 (5.0 – 12.9) | ||
| Single mother/no father present | 1295 | 57.4 (52.3 – 62.5) | 535 | 28.5 (23.7 – 33.2) | 189 | 14.1 (10.5 – 17.7) | ||
| Other | 367 | 69.5 (62.9 – 76.2) | 144 | 23.9 (17.9 – 30.0) | 38 | 6.5 (3.2 – 9.9) | ||
*
Rao-Scott chi-square tests comparing between mild, moderate and severe eczema.