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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Ann Neurol. 2014 Jan 23;75(1):155–160. doi: 10.1002/ana.24016

FIGURE 2.

FIGURE 2

Premortem brain, sural nerve biopsy, and postmortem spinal cord and myocardium. (A) Brain biopsy showing widespread subacute ischemic damage with rarefied neuropil and perivascular lymphocytic infiltrates (hematoxylin and eosin [H&E]). (B) Sural nerve biopsy showing breakdown of myelin (Luxol fast blue/H&E) with (C) Wallerian degeneration on a teased nerve fiber preparation (osmium fixed nerve). (D) Spinal cord ventral horn with neuronal loss and prominent perivascular and parenchymal lymphocytic infiltrates (Luxol fast blue/H&E). (E) Negri body in a residual spinal anterior motor neuron (arrow; Luxol fast blue/H&E). (F) Interatrial cardiac septum with lymphocytic inflammation (H&E). [Color figure can be viewed in the online issue, which is available at www.annalsofneurology.org.]