Table 3. Comparison of the physicochemical properties of α1β1-equivalent interfaces in α, HbA, β4 and γ4 .
IsdHN1–α (α2 interface) | HbA | β4 | γ4 | |
---|---|---|---|---|
Buried area upon complex formation† (Å2) | 1473 | 1802 | 1698 | 1627 |
Polar buried area upon complex formation† (Å2) | 995 | 1172 | 1182 | 1109 |
Nonpolar buried area upon complex formation† (Å2) | 478 | 630 | 516 | 518 |
No. of residues at the interface† | 38 | 49 | 44 | 45 |
Shape complementarity by SC ‡ | 0.80 | 0.65 | 0.74 | 0.73 |