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. 2014 Jul 23;70(Pt 8):1032–1037. doi: 10.1107/S2053230X14012175

Table 3. Comparison of the physicochemical properties of α1β1-equivalent interfaces in α, HbA, β4 and γ4 .

  IsdHN1–α (α2 interface) HbA β4 γ4
Buried area upon complex formation2) 1473 1802 1698 1627
Polar buried area upon complex formation2) 995 1172 1182 1109
Nonpolar buried area upon complex formation2) 478 630 516 518
No. of residues at the interface 38 49 44 45
Shape complementarity by SC 0.80 0.65 0.74 0.73

Calculated using COCOMAPS (Vangone et al., 2011).

Calculated using SC from CCP4 (Lawrence & Colman, 1993).