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One carbon metabolism or methyl transfers in-vivo; shown are folate cycle (black), methionine transmethylation cycle (blue), and the methionine transsulfuration cascade(orange) The flow of methyl groups from serine to methyltransferase is shown in red. THF: tetrahydrofolate; 5 CH3THF: 5 methyl tetrahydrofolate; MS:methionine synthase; SAM: s-adenosyl methionine; SAH: s-adenosylhomocysteine; CβS: cystathionine beta synthase; CγL: cystathionine gamma lyase.
