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Mean ± SD of compartmental pharmacokinetic parameters of dantrolene following administration of a single oral dose of dantrolene at 5 and 10 mg/kg. The range is shown in parenthesis.
| Dose | 5 mg/kg | 10 mg/kg |
|---|---|---|
| λz (/hr) |
0.549 ± 0.6216 (0.109 – 1.618) |
0.574 ± 0.5606 (0.1 – 1.572) |
| t1/2 (hrs) |
1.26 (0.43 – 6.36) |
1.21 (0.44 – 6.93) |
| Ka (/hr) |
0.67 ± 0.3072 (0.219 – 1.154) |
0.557 ± 0.2644 (0.255 – 1.012) |
| Vd/F (L/kg) |
6.18 ± 0.707 (5.409 – 7.309) |
8.39 ± 1.9543 (5.22 – 10.127) |
