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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: J Vet Pharmacol Ther. 2013 Nov 13;37(3):286–294. doi: 10.1111/jvp.12089

Table 2.

Noncompartmental pharmacokinetic parameters of dantrolene following administration of a single oral dose of dantrolene at 5 and 10 mg/kg.

Dog number
Dose
mg/kg		 1 2 3 4 5 6 Mean ± SD
(range)
AUC0-∞
(µg hr / mL) 		5 4.755 0.907 7.123 2.495 7.445 0.494 3.87 ± 3.04
(0.494 – 7.445)
10 4.335 8.387 7.059 2.223 11.409 2.223 5.94 ± 3.67
(2.223 – 11.409)
Relative F 0.46 0.17 1.04 0.12 1.56 0.02 0.56 ± 0.61
(0.02 – 1.56)
MRT0-∞
(hr) 		5 7.37 4.22 7.72 6.16 10.95 2.18 6.43 ± 3.03
(2.18 – 10.95)
10 8.15 8.72 8.13 3.14 15.07 3.14 7.73 ± 4.41
(3.14 – 15.07)
Cmax
(µg/ml) 		5 0.461 0.22 0.762 0.372 0.583 0.199 0.43 ± 0.22
(0.199 – 0.762)
10 0.485 0.745 0.854 0.598 0.618 0.598 0.65 ± 0.13
(0.485 – 0.854)
Cmax ratio 1.05 3.39 1.12 1.61 1.06 3.01 1.87 ± 1.06
(1.05 – 3.39)
Tmax
(hr) 		5 3 1.5 0.75 3 2 0.75 1.83 ± 1.02
(0.75 – 3)
10 3 6 2.5 1.5 2 1.5 2.75 ± 1.7
(1.5 – 6)
CL/F
(L/kg hour) 		5 0.9 5 0.7 1.8 0.7 11.1 3.37 ± 4.13
(0.7 – 11.1)
10 2.3 1.2 1.4 4.5 0.9 4.3 2.4 ± 1.59
(0.9 – 4.5)