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. 2014 Aug 1;9(8):e103125. doi: 10.1371/journal.pone.0103125

Figure 4. Nuclease activity of rSWAN against variable forms of viral DNA and RNA.

Figure 4

(A) The substrate specificity and preference of rSWAN were examined using φX174RF I DNA (double-stranded, mainly super coiled circular), φX174 RF II DNA (double-stranded, mainly nicked circular), and φX174 DNA (single-stranded, mainly circular). Open arrowhead, open circular form; black arrowhead, super coiled form; gray arrowhead, linear form. (B) Total RNA from human keratinocytes was incubated with rSWAN at 37°C for the indicated time periods.