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. 2014 Aug 1;9(8):e103294. doi: 10.1371/journal.pone.0103294

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© 2014 Hufton et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Monovalent and bivalent versions of R1a-B6 (A) and R1a-A5 (B) were compared in neutralisation assays with laboratory adapted X-181 strain [corresponding to A/California/07/2009(H1N1)pdm09], NIBRG-14 [reverse genetics reassortant of A/Vietnam/1194/2004(H5N1)], NIBRG-91 [reverse genetics reassortant of A/chicken/Hong Kong/G9/97(H9N2)], NIBRG-109 [reverse genetics reassortant of A/New York/107/03(H7N2)] and NIBRG-147 [reverse genetics reassortant of A/Singapore/1/57(H2N2)]. Representative curves are shown and are the mean of two replicates. Antibody concentrations are in nM.