Table 1. Single treatment effects of molecular subtype specific drugs on patient-derived GBM cells.
| Subtype | MGMT Status* | Cell | LDA Result (p-value) | |||
| Drug Type** | ||||||
| Classical | Neural | Proneural | Mesenchymal | |||
| Classical | UM | 532T | 0.020 | 1.000 | 0.020 | 1.000 |
| M | 626T | 0.043 | 0.093 | 0.000 | 0.001 | |
| N/A | 099T | 0.000 | 0.000 | 0.000 | 0.000 | |
| N/A | 437T | 0.000 | 0.000 | 0.236 | 0.000 | |
| Neural | UM | 633T | 0.043 | 0.043 | 0.039 | 0.093 |
| Proneural | M | 464T | 0.236 | 1.000 | 0.093 | 1.000 |
| UM | 559T | 0.236 | 1.000 | 0.001 | 1.000 | |
| M | 578T | 0.236 | 1.000 | 0.020 | 1.000 | |
| UM | 448T | 0.236 | 1.000 | 0.004 | 0.009 | |
| Mesenchymal | UM | 592T | 0.020 | 0.043 | 0.236 | 0.043 |
| N/A | 609T | 0.000 | 1.000 | 1.000 | 0.000 | |
| N/A | 316T | 0.000 | 0.395 | 0.698 | 0.009 | |
| N/A | 088T | 0.000 | 0.000 | 0.327 | 0.182 | |
*M = Methylated/UM = Unmethylated/N/A = Not applicable.
**Drug Type (Proneural = Proneural specific treatment, Neural = Neural specific treatment, Classical = Classical specific treatment, Mesenchymal = Mesenchymal specific treatment). The p-value was determined by Chi-Square test that compared with control group (DMSO only). The result “0.000” means that “<0.001”.