Figure 1. Nod1 and Nod2 are not crucial for the inflammatory response during severe polymicrobial sepsis.

Six or 24Nod1- and Nod2-deficient mice (WT, Nod1 ^−/− and Nod2 ^−/−, respectively) underwent CLP-induced severe sepsis they were assessed for: a) neutrophil recruitment to the peritoneal cavity; b) CXCL1 and c) CXCL2 levels in the peritoneal lavage, as measured by ELISA; d) bacterial count in the peritoneal lavage and e) blood; f) IL-6 levels in plasma; g) lung MPO activity. The data were analyzed by multifactorial ANOVA and are expressed as the mean ± SEM in a, b, c, f and g and as median in d and e. The graphs represent the mean of the results of two or three independent experiments. n = 3 to 5 per experiment; ND = not detected.