Figure 6. MyD88 is essential for the resistance to polymicrobial sepsis.

Sepsis was induced in WT and MyD88-deficient mice (WT, MyD88 ^−/−, respectively) using CLP model. The survival curve was observed up to 10 days after the induction of a) non-severe (NS), b) moderate (M), c) severe (S) sepsis or d) after the intraperitoneal inoculation of 1.4×10⁶ cecal-isolated bacteria per mice. The results are expressed as percentage of survival and were analyzed by Mantel-Cox log-rank test. The graphs represent one of one to two independent experiments. N = 5 to 6 per experiment. *P<0.05.