Table 4. Down-regulated genes in blood PMN of CF patients vs. control subjects with biological plausibility.
| Biological process | Accession | Gene coding for | p-value* | Fold change |
| Adhesion | NM_001627 | ALCAM (activated leukocyte cell adhesion molecule) | <0.0001 | −1.83 |
| Apoptosis | NM_181861 | APAF1 (apoptotic peptidase activating factor 1) | 0.021 | − 2.27 |
| Apoptosis | NM_033004 | NLRP1 (NLR family, pyrin domain containing 1) | 0.001 | −1.52 |
| Apoptosis | NM_021127 | PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1) | 0.016 | −1.66 |
| Apoptosis | NM_004938 | DAPK1 (death-associated protein kinase 1) | 0.007 | −1.80 |
| Cell adhesion, autophagy | NM_014385 | SIGLEC7 (sialic acid binding Ig-like lectin 7) | 0.001 | −1.63 |
| Cytoskeleton complex | NM_015326 | SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2) | 0.008 | − 1,57 |
| Immune response, apoptosis | NM_001561 | TNFRSF9 (tumor necrosis factor receptor superfamily, member 9) | 0.0008 | − 2.14 |
| Immune response | NM_001040107 | HVCN1 (hydrogen voltage-gated channel 1) | 0.001 | −1.87 |
| Immune response | NM_014238 | KSR1 (kinase suppressor of ras 1) | 0.009 | −1.66 |
| Immune response | NM_000442 | PECAM1 (platelet/endothelial cell adhesion molecule) | 0.013 | −1.53 |
| Immune response | NM_006863 | LILRA1 (leukocyte immunoglobulin-like receptor, subfamily A) | 0.022 | −1.71 |
| Immune response | NM_000607 | ORM1 (orosomucoid 1) | 0.045 | −2.62 |
| Immune response, signaling | NM_007261 | CD300a | 0.025 | −1.67 |
| Inflammation | NM_020530 | OSM (oncostatin M) | 0.003 | −1.69 |
| Inflammation | NM_001837 | CCR3 (chemokine (C-C motif) receptor 3) | 0.009 | −2.92 |
| Inflammation | NM_005211 | CSF1R (colony stimulating factor 1 receptor) | 0.016 | −1.75 |
| Inflammation | NM_006639 | CYSLTR1(cysteinyl leukotriene receptor 1) | 0.009 | −1.66 |
| Oxidative burst | NM_001693 | ATP6V1B2 (ATPase, H+ transporting, lysosomal) | 0.037 | −1.51 |
| Pathogen defence | NM_000081 | LYST (lysosomal trafficking regulator) | 0.026 | − 1.86 |
| Signal Transduction | NM_006990 | WASF2 (WAS protein family, member 2) | 0.009 | − 1.41 |
| Signal transduction | NM_004041 | ARRB1 (Arrestin beta1) | 0.004 | − 1.79 |
| Signal transduction | NM_207345 | CLEC9A (C-type lectin domain family 9) | 0.008 | − 1.51 |
| Signal transduction | NM_006779 | CDC42EP2 (CDC42 effector protein (Rho GTPase binding 2) | 0.016 | −1.68 |
*from unpaired t-test.