Table 6. Down-regulated genes in airway PMN of CF patients post-therapy vs. pre-therapy with biological plausibility.

Biological process	Accession	Gene coding for	p-value*	Fold change
Apoptosis	NM_014143	CD274	0.0043	−2.22
Apoptosis	NM_033306	CASP4 (caspase 4)	0.0176	−1.68
Apoptosis	NM_004536	NAIP (NLR family, apoptosis inhibitory protein)	0.0323	−2.08
Immune response	NM_000544	TAP2 (transporter 2, ATP-binding cassette, sub-family B)	0.0012	−1.42
Immune response	NM_014879 14	P2RY14 (purinergic receptor P2Y, G-protein coupled)	0.0113	−1.56
Immune response	NM_006573	TNFSF13B (tumor necrosis factor (ligand) superfamily, member 13b)	0.0116	−1.56
Immune response	NM_003004	SECTM1 (secreted and transmembrane 1)	0.0240	−1.53
Immune response	NM_002198	IRF1 (interferon regulatory factor 1)	0.0345	−1.84
Inflammation	NM_024807	TREML2 (triggering receptor expressed on myeloid cells-like 2)	0.0003	−1.40
Inflammation	NM_006639	CYSLTR1 (cysteinyl leukotriene receptor 1)	0.0070	−1.76
Inflammation	NR_024168	TLR4 (toll-like receptor 4)	0.0178	−1.43
Inflammation	NM_020370	GPR84 (G protein-coupled receptor 84)	0.0247	−1.81
Inflammation	NM_000062	SERPING1 (serpin peptidase inhibitor)	0.0459	−1.51
Signal transduction	NM_016511	CLEC1a (C-type lectin domain family 1)	0.0010	−1.45
Signal transduction	NM_002053	GBP1 guanylate binding protein 1, interferon-inducible,	0.0021	−2.42
Signal transduction	NM_207345	CLEC9A (C-type lectin domain family 9)	0.0052	−1.43
Signal transduction	NM_005419	STAT2 (signal transducer and activator of transcription 2)	0.0079	−1.90
Signal transduction	NM_007315	STAT1 (signal transducer and activator of transcription 1)	0.0083	−1.81
Signal transduction	NM_003608	GPR65 (G protein-coupled receptor 65)	0.0117	−1.62
Signal transduction	NM_018284	GBP3 (guanylate binding protein 3)	0.0186	−1.81
Signal transduction	NM_004120	GBP2 (guanylate binding protein 2, interferon-inducible)	0.0216	−1.51
Signal transduction	NM_052941	GBP4 (guanylate binding protein 4)	0.0313	−1.67

*from paired t-test.