Figure 4.

Two examples of hypothesized adverse outcome pathways (AOPs) for the key event of impaired swim bladder inflation (black background). (A) Hypothesized AOP linking glycogen synthase kinase 3β inhibition to reduced young-of-year (y.o.y) survival in fish via impacts on swim bladder inflation; (B) hypothesized AOP linking impaired gas gland cell mucus secretion to reduced young-of-year survival via impacts on swim bladder inflation. GSK3B = glycogen synthase kinase 3β; MIE = molecular initiating event; TBC = tris(2,3-dibromopropyl)isocyanurate.