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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Pain. 2014 Apr 20;15(7):726–733. doi: 10.1016/j.jpain.2014.04.002

Figure 1.

Figure 1

Effect of intrathecally (i.t.) administered antisense (AS, open bars) or mismatch (MM, solid bars) oligodeoxynucleotides (ODN) on mechanical hyperalgesia exhibited by rats submitted to a model of endometriosis pain induced by implanting uterine tissue on the gastrocnemius muscle (Alvarez et al., 2012). Two weeks after surgical implant of autologous uterine tissue, rats displayed a marked mechanical hyperalgesia (EMS, endometriosis pain model), compared to pre-operative baseline (Pre-op). The effects of i.t. AS or MM ODN (80 μg) on mechanical hyperalgesia at the site of surgical implant were assessed every other day up to day 5 after last ODN injection. (A) Effect of AS (n = 8) or MM (n = 6) ODN directed against mRNA for the glycoprotein 130 (gp130) subunit of the IL-6 receptor signaling complex. (B) Effect of AS (n = 8) or MM (n = 6) ODN directed against mRNA for the tumor necrosis receptor 1 (TNFR1). (C) Effect of AS (n = 5) or MM (n = 5) ODN directed against mRNA for the NGF tyrosine kinase receptor A (TrkA). ***P < 0.001; *P < 0.05.