Table 2.
Factors Associated with Conversion to AD (p<0.20) Within Each Domain
| Characteristic | 3-Year Conversion to AD | Domain-Specific HR (95% CI) |
|---|---|---|
| Demographic | ||
| Gender | ||
| Male | 45.1% | 1 |
| Female | 53.5% | 1.33 (0.96,1.84) |
| Marital status | ||
| Not married | 47.4% | 1 |
| Married | 48.3% | 1.34 (0.88, 2.04) |
| Symptoms/vital signs | ||
| Functional dependence (FAQ) score | ||
| Lowest quartile (0) | 21.4% | 1 |
| Second quartile (1–2) | 43.0% | 2.47 (1.46,4.16) |
| Third quartile (3–6) | 57.6% | 3.99 (2.44,6.53) |
| Highest quartile (≥ 7) | 79.9% | 6.81 (4.16,11.17) |
| Neuropsychiatric symptoms (NPI) | ||
| <4 | 44.4% | 1 |
| ≥4 | 66.2% | 1.46 (1.01,2.11) |
| Body mass index (kg/m2) | ||
| ≥22 | 45.3% | 1 |
| <22 | 62.0% | 1.47 (1.01, 2.15) |
| Insomnia | ||
| Yes | 38.9% | 1 |
| No | 49.4% | 1.60 (0.97,2.64) |
| MRI variables | ||
| Hippocampal subcortical volume, mm3 | ||
| Highest quartile (3546–4716.5) | 25.6% | 1 |
| Third quartile (3132.5–3546) | 37.9% | 1.35 (0.80, 2.27) |
| Second quartile (2792.5–3132.5) | 53.7% | 1.60 (0.93, 2.75) |
| Lowest quartile (1640.5–2792.5) | 76.3% | 2.08 (1.18, 3.67) |
| Entorhinal cortical volume, mm3 | ||
| Highest quartile (1908.5–2830) | 23.5% | 1 |
| Third quartile (1640.25–1908.5) | 39.0% | 1.59 (0.92, 2.73) |
| Second quartile (1354.4–1640.25) | 60.6% | 2.01 (1.17, 3.44) |
| Lowest quartile (779–1354.4) | 70.7% | 2.31 (1.30, 4.10) |
| Middle temporal cortical thickness, mm | ||
| Highest quartile (2.761–3.052) | 30.7% | 1 |
| Third quartile (2.624–2.761) | 32.3% | 1.17 (0.71,1.92) |
| Second quartile (2.48–2.624) | 51.3% | 1.69 (1.05,2.72) |
| Lowest quartile (1.781–2.48) | 80.7% | 2.85 (1.80,4.54) |
| Genetic/blood-based biospecimens | ||
| APOE e4 | ||
| No e4 alleles | 35.1% | 1 |
| ≥1 e4 alleles | 59.1% | 1.86 (1.36,2.56) |
| Neuropsychological measures | ||
| ADAS-cog, total score | ||
| Lowest quartile (3–14.33) | 13.7% | 1 |
| Second quartile (14.34–18.67) | 48.5% | 2.90 (1.59,5.27) |
| Third quartile (18.68–23.00) | 65.8% | 3.76 (2.04,6.93) |
| Highest quartile (>23.00) | 68.1% | 3.82 (2.04,7.15) |
| RAVLT Trial 6, words recalled | ||
| Highest quartile (≥ 5) | 13.2% | 1 |
| Third quartile (4–5) | 46.8% | 2.00 (0.95,4.20) |
| Second quartile (2–3) | 65.1% | 2.54 (1.17,5.52) |
| Lowest quartile (0–1) | 65.8% | 2.41 (1.09,5.31) |
| RAVLT delayed, words recalled | ||
| Highest quartile (≥ 5) | 17.6% | 1 |
| Third quartile (3–4) | 45.1% | 1.14 (0.58, 2.25) |
| Second quartile (1–2) | 53.4% | 1.08 (0.55, 2.13) |
| Lowest quartile (0) | 69.6% | 1.63 (0.83, 3.20) |
| Clock Test score | ||
| 4–5 | 42.2% | 1 |
| 0–3 | 71.0% | 1.57 (1.11,2.23) |
| Trail Making Test-B, seconds | ||
| Lowest quartile (0–76) | 35.7% | 1 |
| Second quartile (77–105.5) | 42.7% | 0.98 (0.61, 1.56) |
| Third quartile (105.5–165) | 50.8% | 1.44 (0.92, 2.26) |
| Highest quartile (>165) | 65.8% | 1.61 (1.03, 2.51) |