Table 4.
MGH-SFI item |
Bupropion plus aripiprazole, mean (SE) |
SSRI/SNRI plus aripiprazole, mean (SE) |
||||
---|---|---|---|---|---|---|
Baseline | Change from baseline at Week 52 (OC) | Change from baseline at Week 52 (LOCF) | Baseline | Change from baseline at Week 52 (OC) | Change from baseline at Week 52 (LOCF) | |
Males, n |
13 |
5 |
13 |
69 |
21 |
69 |
Interest in sex |
2.8 (0.3) |
-0.2 (0.9) |
0.0 (0.4) |
3.8 (0.2) |
-0.5 (0.4) |
-0.3 (0.2) |
Ability to get sexually aroused |
3.1 (0.3) |
0.0 (0.8) |
-0.1 (0.3) |
3.9 (0.2) |
-0.8 (0.3) |
-0.3 (0.2) |
Ability to achieve orgasm |
3.2 (0.4) |
-0.4 (1.1) |
-0.2 (0.4) |
4.0 (0.2) |
-0.7 (0.4) |
-0.4 (0.2) |
Ability to get erection |
3.7 (0.4) |
-1.2 (0.4) |
-0.6 (0.2) |
3.7 (0.2) |
-0.3 (0.4) |
-0.2 (0.2) |
Overall sexual satisfaction |
3.9 (0.4) |
-1.4 (0.2) |
-0.7 (0.3) |
4.1 (0.2) |
-0.6 (0.3) |
-0.4 (0.2) |
Females, n |
24 |
14 |
24 |
147 |
48 |
147 |
Interest in sex |
3.9 (0.3) |
-0.5 (0.3) |
-0.5 (0.3) |
4.6 (0.1) |
-0.9 (0.2) |
-0.9 (0.1) |
Ability to get sexually aroused |
4.0 (0.3) |
-0.4 (0.5) |
-0.5 (0.3) |
4.6 (0.1) |
-0.9 (0.2) |
-0.7 (0.1) |
Ability to achieve orgasm |
3.9 (0.4) |
-0.3 (0.5) |
-0.3 (0.3) |
4.6 (0.1) |
-0.8 (0.2) |
-0.7 (0.1) |
Overall sexual satisfaction | 4.1 (0.3) | -0.8 (0.4) | -0.7 (0.3) | 4.7 (0.1) | -1.1 (0.2) | -0.8 (0.1) |
ADT, antidepressant treatment; LOCF, last observation carried forward; MGH-SFI, Massachusetts General Hospital Sexual Functioning Inventory; OC, observed case; SNRI, serotonin–norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor.
MGH-SFI item scores range from 1 (greater than normal) to 6 (totally absent). A negative change score signifies improvement.