Table 1. Overview of different models for glucocorticoid-induced bone loss given in the reported dose.
Strain | Gender | Age (weeks) | Pellet dose (mg)a | Doseb (mg per kg BW per d) | Duration (weeks) | Source |
---|---|---|---|---|---|---|
FVB/N | Female | 24 | 3.5 | 4 | 3 | |
Intercross: Black Swiss and 129SvJ | Male | 32 | 5 | 2.1 | 4 | 1,4 |
Swiss Webster | Male | 24 | 5 | 0–8 | 5 | |
Swiss Webster | Male | 28 | 2.1 | 8 | 2 | |
Swiss Webster | Male | 24 | 1.4 | 3 | 6 | |
FVB/N, 129SvJ | Female | 10 | 15 | 12.5 | 2 | 7 |
C57BL/6 | Male | 20 | 7.5 | 4 | 8 |
Abbreviations: BW, body weight; d, day.
aUsing 60-day slow-release pellets
bFor scaling the dose per mouse to the equivalent dose in humans, the dose per kg BW should be calculated with the weight in relation to the metabolic rate (for mice, weight in kg to the ¾ power9).