Table 1. Diverse functional interactions of APE1/Ref-1 with various proteins.
| Sr. no. | Interacting protein (reference) |
|---|---|
| APE1 | |
| BER proteins | |
| 1 | XRCC113 |
| 2 | DNA ligase IIIα236 |
| 3 | Pol β237 |
| 4 | FEN115, 236 |
| 5 | GADDα modulates APE1 activity by directly interacting with PCNA238 |
| 6 | PCNA15 |
| 7 | PARP1239 |
| 8 | GAPDH240 |
| Transcriptional proteins | |
| 1 | Egr-121 |
| 2 | NF-κB132 |
| 3 | p5321 |
| 4 | HIF-1α21 |
| 5 | CREB21 |
| 6 | AP-1 (c-Jun)21 |
| 7 | Pax-821 |
| 8 | STAT37, 161 |
| 9 | p3007 |
| 10 | HDAC17 |
| Other proteins | |
| 1 | YB-124 |
| 2 | anti-NGF 3026 |
| 3 | PKM226 |
| 4 | hn-RNA-H26 |
| 5 | Tmod326 |
| 6 | N-acetyltransferase CML126 |
| 7 | Sphingosine 1-phosphate phosphatase 1 isoform26 |
| 8 | Leucine-rich and death domain-containing26 |
| 9 | Tropomyosin alpha-3 chain isoform 126 |
| 10 | Sulfotransferase 1C226 |
| 11 | NPM192 |
| 12 | HSP70121 |
| 13 | Nm23-H1241 |
| 14 | SIRT1 protein deacetylase242 |
| 15 | Bcl2243 |
Abbreviations: anti-NGF 30, anti-nerve growth factor 30 antibody heavy-chain; AP-1, activator protein 1; APE1, apurinic/apyrimidinic endonuclease 1; BER, base excision repair; CREB, cAMP response element-binding; FEN1, Flap endonuclease 1; GADDα, growth arrest and DNA damage alpha; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HDAC1, histone deacetylase 1; HIF-1α, hypoxia inducible factor 1α hn-RNA-H1, heterogeneous nuclear ribonucleoprotein-H1; HSP70, human heat shock protein 70; NF-κB, nuclear factor kappa B; Nm23-H1, non-metastatic protein-23 homolog-1; NPM1, nucleophosmin; PARP1, poly (ADP-ribose) polymerase 1; PCNA, proliferating cell nuclear antigen; PKM2, pyruvate kinase 3 isoform 2; Ref-1, redox effector factor-1; SIRT1, SIRTUIN1; STAT3, signal transducer activator of transcription 3; Tmod3, tropomodulin 3; XRCC1, X-ray cross complementation protein 1.