Table 2. Classification of the analyzed immune genes according to the M1/M2 paradigm (see references 62,63,64,65,66).
| Gene | Phenotype |
|---|---|
| ccl1 | M2b |
| ccl2 | Both M1 and M2 |
| ccl3 | M1 |
| ccl4 | M1 |
| ccl5 | M1 |
| ccl11 | M2 |
| ccl20 | No confirmed association |
| ccl22 | M2 |
| cxcl10 | M1 |
| cc3 | No confirmed association |
| ccr4 | No confirmed association |
| ccr5 | M1 |
| ccr6 | No confirmed association |
| ccr7 | M1 |
| cxcr5 | No confirmed association |
| il1α | M1 |
| il1β | M1 |
| il4 | M2 |
| il6 | M1 |
| il10 | M2 |
| il17 | No confirmed association |
| ifnγ | M1 |
| tgfβ | No confirmed association |
| tnfα | M1 |
| CD25/il2ra | No confirmed association |
| foxp3 | No confirmed association |
It should be noted that not all the analyzed genes have been clearly linked to one of the two activation phenotypes. In addition, genes that have been linked to monocyte/macrophage polarization can have important roles in other cell types such as T-helper cells.