Figure 5.

A parallel-Ising kinetic model for CARP(Ala) folding kinetics. (A) Folding mechanism of NR₃C(Ala). The first step involves folding two contiguous repeats; subsequent steps involve folding an adjacent repeat. The magnitude of folding flux is indicated by arrow thickness. (B) Three elementary nucleation and propagation steps are sufficient to model all CARPs (see Fig. S2). (C) Energy landscape of NR₃C(Ala), constructed with parameters obtained from the parallel-Ising kinetic model. The ground-states and barriers are colored according to their free energies. The folded region of each ground state is depicted on the energy level. The grayscale intensity of the paths between neighboring states is proportional to the magnitude of the folding flux. To see this figure in color, go online.