Figure 6.

The parallel-Ising kinetic model captures the folding and unfolding kinetics of CARP(Ala) constructs of various length and capping structures at different GdnHCl concentrations. (A) Comparison of eigenvalues obtained from the parallel-Ising global fit to fluorescence kinetic traces and CD-detected equilibrium unfolding transitions (lines, see Fig. S9, A and C) with rate constants (points) obtained from the model-free multiexponential fitting. The area of each point marker is proportional to its fitted kinetic amplitude; only eigenvalues and rate constants with relative amplitude higher than 10% are shown. (B) The parallel-Ising model captures the increase in the folding rates with repeat number for all constructs; only major phases are shown here for clarity. To see this figure in color, go online.