Table 2. Mean Skin Reflectance and Nevi count for each TYR haplotype.
| TYR phasea | TYR proteinb | Allele Strengthc | Proposed Frequency (95% CI) | Inner arm % reflectance (SD)d | Outer arm % reflectance (SD)d | Nevi (95%CI)e,f |
|---|---|---|---|---|---|---|
| 1-1 | S-R | 3 | 0.36 (0.34-0.37) | 61.8 (0.14) | 52.5 (0.21) | 89.8 (86.1-93.7) |
| 2-1 | Y-R | 2 | 0.33 (0.31-0.34) | 62.4 (0.14) | 53.4 (0.22) | 90.6 (86.6-94.8) |
| 1-2 | S-Q | 1 | 0.29 (0.29-0.31) | 62.9 (0.15) | 53.6 (0.22) | 97.6 (93.1-102.3) |
| 2-2 | Y-Q | 0 | 0.017 (0.016-0.023) | 63.5 (0.34) | 53.6 (0.52) | 110.8 (99.1-123.9) |
a
Designated for rs1042602*C/A = 1/2 - rs1126809*G/A = 1/2
b
Protein phases designated at S192Y-R402Q as 192S = 1, 192Y = 2; 402R = 1, 402Q = 2
c
Based on a four point scale S-R = 3, Y-R =2, S-Q =1, Y-Q = 0
d
Sample set of 2287 for skin relectance, and
e
Sample set of 1,979 for nevi counts, in BTNS and/or melanoma cases in which haplotype phase was predicted from the MENDEL program
f
Geometric mean with 95% confidence interval.