Table 4. Mean Skin Reflectance and Nevi count for each TYR genotype.
| TYR genotypea | TYR genotype phaseb | TYR protein phasec | Combined Allelic Strengthd | Skin Reflectancee | Nevif | ||||
|---|---|---|---|---|---|---|---|---|---|
| N (%) | Inner arm (SD) % | Outer arm (SD) % | N (%) | Log Count (SD) | Mean Count | ||||
| A | 1-1/1-1 | S-R/S-R | 6 | 242 (12.9) | 61.06 (5.40) | 51.61 (7.291) | 262 (13.2) | 1.9048 (0.3003) | 80.3 |
| B | 1-1/2-1 | S-R/Y-R | 5 | 457 (24.3) | 61.61 (3.92) | 52.69 (5.82) | 480 (24.3) | 1.9406 (0.2457) | 87.2 |
| C | 1-1/1-2 | S-R/S-Q | 4 | 380 (20.3) | 62.02 (3.88) | 53.09 (5.81) | 396 (20.0) | 1.9764 (0.2396) | 94.7 |
| E | 2-1/2-1 | Y-R/Y-R | 4 | 206 (11.0) | 62.04 (3.62) | 53.35 (6.72) | 220 (11.1) | 1.9322 (0.2201) | 85.5 |
| D/F | 1-1/2-2 2-1/1-2 | S-R/Y-Q Y-R/S-Q | 3 | 383 (20.4) | 62.32 (3.25) | 53.17 (5.46) | 406 (20.5) | 1.9500 (0.2446) | 89.1 |
| G | 2-1/2-2 | Y-R/Y-Q | 2 | 19 (1.0) | 64.42 (2.45) | 56.63 (12.32) | 20 (1.0) | 2.0672 (0.2207) | 116.7 |
| H | 1-2/1-2 | S-Q/S-Q | 2 | 167 (8.9) | 63.34 (3.68) | 53.89 | 173 (8.7) | 2.0013 (0.2462) | 100.3 |
| I | 1-2/2-2 | S-Q/Y-Q | 1 | 21 (1.1) | 64.19 (3.10) | 54.05 (7.46) | 22 (1.1) | 1.9457 (0.2604) | 88.2 |
| J | 2-2/2-2 | Y-Q/Y-Q | 0 | 0 (0) | Nil (Nil) | Nil (Nil) | 0 (0) | Nil (Nil) | Nil (Nil) |
a, b
Genotypes designated in Table S3 for rs1042602*C/A and rs1 126809*G/A
c
Protein phases designated at S192Y-R402Q as 192S = 1, 192Y = 2; 402R = 1, 402Q = 2
d
Based on a four point scale S-R = 3, Y-R =2, S-Q =1, Y-Q = 0
e
Sample set of 1875 for skin reflectance,
f
Sample set of 1,979 for nevi counts in BTNS and/or melanoma study samples in which genotype phase has been determined
f
Geometric mean with standard deviation.