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Model showing how RARRES3 suppression contributes to ER− breast cancer primary tumors metastasis to the lung. This suppression enables adhesion to the lung parenchyma, thus facilitating seeding at the lungs. Moreover, RARRES3 suppression and loss of its PLA1/2 catalytic activity disable differentiation signals, which, in turn, provide metastasis initiation competence to breast cancer cells to colonize the lung.
