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. 2014 Feb 4;18(5):863–874. doi: 10.1111/jcmm.12232

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© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

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Fig. 3 — Expression of Olfactomedin 4 (OLFM4) is regulated by the oestrogen receptor-α (ERα) signalling in endometrial carcinoma cells. (A and B) Oestrogen antagonist ICI 182 780 attenuated the OLFM4 mRNA increase induced by E₂. (C and D) ERα-specific agonist PPT, but not ERβ-specific agonist DPN, induced OLFM4 mRNA expression. (E–H) Knockdown of ERα with siRNA reduced E₂-induced expression of OLFM4. *P < 0.05, **P < 0.001. E₂, 17β-estradiol; ICI, ICI 182 780; PPT, 4′,4″,4‴-(4- propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol; DPN, 2,3-bis-(4–ydroxyphenyl)–propionitrile; BC: blank control; NC: negative control (non-specific siRNA group).